Its unique and distinctive natural defenses help compensate for its slow locomotion, which would make him a comparatively easy target. The pufferfish’s excellent eyesight is the first and most important protection against predators. The puffer’s neurotoxin is found primarily in the ovaries and liver, although smaller amounts exist in the intestines and skin, as well as trace amounts in muscle. If there is threat, the puffer quickly pumps water in its stomach and blows up, the enlargement is almost spherical in shape.